The Biology of Interleukin-2 (Annual Review of Immunology Book 26) Thomas R. Malek

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Published: February 1st 2012

Kindle Edition

49 pages


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The Biology of Interleukin-2 (Annual Review of Immunology Book 26)  by  Thomas R. Malek

The Biology of Interleukin-2 (Annual Review of Immunology Book 26) by Thomas R. Malek
February 1st 2012 | Kindle Edition | PDF, EPUB, FB2, DjVu, audiobook, mp3, ZIP | 49 pages | ISBN: | 9.31 Mb

Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early paradigm in which IL-2 is central for protective immune responses. This change in thinking occurred when a T regulatory cellMoreMuch data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early paradigm in which IL-2 is central for protective immune responses. This change in thinking occurred when a T regulatory cell defect was shown to be responsible for the lethal autoimmunity associated with IL-2/IL-2R deficiency.

This realization allowed investigators to explore immune responses in IL-2-nonresponsive mice rendered autoimmune-free. Such studies established that IL-2 sometimes contributes to optimal primary immune responses, but it is not mandatory. Emerging findings, however, suggest an essential role for IL-2 in immune memory. Here, the current understanding of the dual role of IL-2 in maintaining tolerance and contributing to immunity in vivo is reviewed with some emphasis on T regulatory cell production and homeostasis. Also discussed are implications of this new appreciation concerning the immunobiology of IL-2 with respect to targeting IL-2 or its receptor in immunotherapy.



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